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- Title
Assessing Variability by Joint Sampling of Alignments and Mutation Rates.
- Authors
Metzler, Dirk; Flei&szling;ner, Roland; Wakolbinger, Anton; von Haeseler, Arndt
- Abstract
When two sequences are aligned with a single set of alignment parameters, or when mutation parameters are estimated on the basis of a single ``optimal'' sequence alignment, the variability of both the alignment and the estimated parameters can be seriously underestimated. To obtain a more realistic impression of the actual uncertainty, we propose sampling sequence alignments and mutation parameters simultaneously from their joint posterior distribution given the two original sequences. We illustrate our method with human and orangutan sequences from the hyper variable region I and with gene–pseudogene pairs.
- Subjects
GENETIC mutation; GENETICS; BIOLOGICAL variation; ANIMAL mutation; GENES; HEREDITY
- Publication
Journal of Molecular Evolution, 2001, Vol 53, Issue 6, p660
- ISSN
0022-2844
- Publication type
Article
- DOI
10.1007/s002390010253