We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Anatomic and clinical correlates of septal morphology in hypertrophic cardiomyopathy.
- Authors
Turer, Aslan T.; Samad, Zainab; Valente, Anne Marie; Parker, Michele A.; Hayes, Brenda; Kim, Raymond J.; Kisslo, Joseph; Wang, Andrew
- Abstract
Aim The presence of septal hypertrophy in hypertrophic cardiomyopathy (HCM) is common. To date, there has been no accepted classification of septal morphology in HCM. Furthermore, the possible relationship between septal morphology and clinical features of HCM is undefined. Methods and results Seventy-five consecutive adult patients with HCM were enrolled. Septal morphologies were retrospectively categorized into one of four patterns of hypertrophy based on transthoracic echocardiography. Left ventricular diastolic function by Doppler echocardiography and late gadolinium enhancement (LGE) by magnetic resonance imaging were assessed in all patients. Patients were followed for a mean of 45 ± 32 months. Catenoid septum was the most common morphologic subtype (46 of 75, 61%), followed by simple sigmoid (22 of 75, 29%), neutral (4 of 75, 5%), and apical (3 of 75, 4%). Inter-observer reproducibility of septal classifications was high (κ = 0.95). Patients with the catenoid subtype presented at a younger age, had worse diastolic function, and high rates of LGE. The presence of catenoid septal morphology was independently associated with LGE in multivariable logistic regression analysis. Implantable cardioverter-defibrillator implantation for prevention of sudden cardiac death occurred only in patients with this septal morphology. Conclusion We propose a simple, reproducible classification system of patterns of septal hypertrophy in HCM. These patterns of hypertrophy are associated with significant differences in clinical, haemodynamic, and myocardial characteristics. Further studies are needed to evaluate the relationship between septal morphology and outcome or response to therapies in HCM.
- Subjects
HYPERTROPHIC cardiomyopathy; CARDIAC surgery; ANALYSIS of variance; COMPUTER software; CONFIDENCE intervals; DIASTOLE (Cardiac cycle); DOPPLER echocardiography; EPIDEMIOLOGY; FISHER exact test; LEFT heart ventricle; HEART septum; LONGITUDINAL method; MAGNETIC resonance imaging; HEALTH outcome assessment; STATISTICAL sampling; STATISTICAL hypothesis testing; STATISTICS; DATA analysis; MULTIPLE regression analysis; TREATMENT effectiveness; INTER-observer reliability; RETROSPECTIVE studies
- Publication
European Journal of Echocardiography, 2011, Vol 12, Issue 2, p131
- ISSN
1525-2167
- Publication type
Article
- DOI
10.1093/ejechocard/jeq163