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- Title
Occipital ganglio-neuroblastoma in an adult.
- Authors
Sabatino, Giovanni; Lauriola, Libero; Sioletic, Stefano; Puca, Alfredo
- Abstract
Ganglioneuroblastomas (GNBs) are embryonic neoplasms, whose behaviour are not well established; 80% of cases occur in the first decade, while only two cases in the adulthood had been reported. This 60-year-old female presented with a 2-month history of headache, vertigo, amnesia. A right brachio-crural hemiparesis, right homonymous hemianopsia and sensorial dysphasia was evident. A CT scan revealed a left occipital lesion. MRI scan was not performed because the patient had an anal sphincter stimulator. Three years before thyroidectomy for a follicular carcinoma was performed. A total body CT scan was negative. A left occipital craniotomy was carried out and a solid mass was totally excised. A diagnosis of GNB was made from histopathological examination and immunohistochemistry. Post-operatively the patient recovered from the hemiparesis while the visual disturbances persisted. She underwent fractioned radiotherapy (60 Gy) and chemotherapy with Temozolomide. She remained disease free 18 months after diagnosis. A CT scan showed no evidence of recurrence. Recent observations suggest that in spite of an embryonal appearance, these tumours are circumscribed and have a better prognosis than malignant gliomas.
- Subjects
NEUROBLASTOMA; HEADACHE; VERTIGO; AMNESIA; HEMIANOPSIA; LANGUAGE disorders; THYROIDECTOMY; IMMUNOHISTOCHEMISTRY
- Publication
Acta Neurochirurgica, 2009, Vol 151, Issue 5, p495
- ISSN
0001-6268
- Publication type
Article
- DOI
10.1007/s00701-009-0227-3