We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Effect of wild ginseng on scopolamine-induced acetylcholine depletion in the rat hippocampus.
- Authors
Lee, Bombi; Park, Jongbong; Kwon, Sunoh; Park, Moo-Won; Oh, Sang-Muk; Yeom, Mi-Jung; Shim, Insop; Lee, Hye-Jung; Hahm, Dae-Hyun
- Abstract
Objectives The ameliorating effects of wild ginseng on learning and memory deficits were investigated in rats. Methods Rats were treated daily with wild ginseng or cultivated ginseng for 7 days at 30 min before scopolamine injection (2 mg/kg, i.p.). After inducing cognitive impairment by the administration of scopolamine, behavioural assessment using the Morris water maze was performed. Changes in cholinergic system reactivity were also examined by measuring the immunoreactive neurons of choline acetyltransferase and the reactivity of acetylcholinesterase in the hippocampus. Key findings Scopolamine injection induced impaired performance in the water maze test and severe cell losses in hippocampal cholinergic neurons, as indicated by decreased choline acetyltransferase immunoreactivity and increased acetylcholinesterase reactivity. Daily administration of wild ginseng produced a significant improvement in the escape latency for finding the platform in the Morris water maze and reduced the loss of cholinergic immunoreactivity in the hippocampus. The reduced expression of brain-derived neurotrophic factor mRNA due to the scopolamine injection was recovered to normal levels by the administration of wild ginseng. Conclusions Wild ginseng demonstrates a significant neuroprotective effect against scopolamine-induced neuronal and cognitive impairment.
- Subjects
GINSENG; SCOPOLAMINE; ACETYLCHOLINE; HIPPOCAMPUS (Brain); LABORATORY rats
- Publication
Journal of Pharmacy & Pharmacology, 2010, Vol 62, Issue 2, p263
- ISSN
0022-3573
- Publication type
Article
- DOI
10.1211/jpp.62.02.0015