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- Title
ChemHub: a knowledgebase of functional chemicals for synthetic biology studies.
- Authors
Han, Mengying; Zhang, Dachuan; Ding, Shaozhen; Tian, Yu; Cheng, Xingxiang; Yuan, Le; Sun, Dandan; Liu, Dongliang; Gong, Linlin; Jia, Cancan; Cai, Pengli; Tu, Weizhong; Chen, Junni; Hu, Qian-Nan
- Abstract
Summary The field of synthetic biology lacks a comprehensive knowledgebase for selecting synthetic target molecules according to their functions, economic applications and known biosynthetic pathways. We implemented ChemHub, a knowledgebase containing >90 000 chemicals and their functions, along with related biosynthesis information for these chemicals that was manually extracted from >600 000 published studies by more than 100 people over the past 10 years. Availability and implementation Multiple algorithms were implemented to enable biosynthetic pathway design and precursor discovery, which can support investigation of the biosynthetic potential of these functional chemicals. ChemHub is freely available at: http://www.rxnfinder.org/chemhub/. Supplementary information Supplementary data are available at Bioinformatics online.
- Subjects
CHEMICAL biology; CHEMICAL potential; SYNTHETIC biology; BIOSYNTHESIS
- Publication
Bioinformatics, 2021, Vol 37, Issue 22, p4275
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btab360