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- Title
Effect of olanzapine and risperidone on subjective well-being and craving for cannabis in patients with schizophrenia or related disorders: a double-blind randomized controlled trial.
- Authors
van Nimwegen, Lonneke J.; de Haan, Lieuwe; van Beveren, Nico J. M.; van der Helm, Mischa; van den Brink, Wim; Linszen, Don; van Beveren, Nico Jm
- Abstract
<bold>Objective: </bold>To examine whether subjective well-being and craving for cannabis were different in patients with schizophrenia or related disorders treated with either olanzapine or risperidone. <bold>Method: </bold>A 6-week, double-blind, randomized trial of olanzapine and risperidone was carried out in 128 young adults with recent onset schizophrenia or related disorders. Primary efficacy measures were the mean baseline-to-endpoint change in total scores on the Subjective Well-Being under Neuroleptics scale, the Obsessive-Compulsive Drug Use Scale, the Drug Desire Questionnaire, and the cannabis use self-report. An analysis of covariance was used to test between-group differences. <bold>Results: </bold>Estimated D(2) receptor occupancy did not differ between olanzapine (n = 63) and risperidone (n = 65). Similar improvements in subjective well-being were found in both groups. In the comorbid cannabis-using group (n = 41, 32%), a similar decrease in craving for cannabis was found in both treatment conditions. <bold>Conclusions: </bold>Both olanzapine and risperidone were associated with improved subjective well-being. No evidence was found for a differential effect of olanzapine or risperidone on subjective experience or on craving for cannabis in dosages leading to comparable dopamine D(2) occupancy. <bold>Clinical Trial Registration Number: </bold>ISRCTN46365995.
- Subjects
SCHIZOPHRENIA; DRUGS of abuse; OLANZAPINE; YOUNG adults; REGRESSION analysis; ANTIPSYCHOTIC agents; DRUG efficacy; CANNABIS (Genus); RISPERIDONE
- Publication
Canadian Journal of Psychiatry, 2008, Vol 53, Issue 6, p400
- ISSN
0706-7437
- Publication type
journal article
- DOI
10.1177/070674370805300610