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- Title
Acquired Isolated FVII Deficiency.
- Authors
Girolami, Antonio; Santarossa, Claudia; Cosi, Elisabetta; Ferrari, Silvia; Lombardi, Anna Maria
- Abstract
Objective: To investigate all cases of isolated factor VII (FVII) deficiency as gathered from personal files or by a PubMed search. Patients and Methods: Personal files dealing with patients studied in Padua during the years 1970 to 2010 were reevaluated. The PubMed search was time unlimited and was carried on 2 occasions during 2014. Cross-checking of the references, listed in every article, was also carried out to avoid omissions. Inclusion criteria were isolated FVII defect of less than 40% of normal, negative coagulation pattern in the family, normal level of other vitamin K-dependent clotting factors, and normalization of the clotting factor after the therapeutic procedures, unless the patient died. Results: Twenty-nine patients met the inclusion criteria (18 male and 9 female, in 2 cases gender was unreported). This number included 1 personal case. Mean age was 37.9 (range 3-80). Underlying diseases were the following: neoplasia, infections, polytrauma, penicillin administration, nephrotic syndrome Wiskott Aldrich syndrome, and left heart failure (1 case, each); 2 patients had no underlying disease. Bleeding was variable but usually mild. There were 11 fatalities. Conclusions: Isolated FVII deficiency is a rare defect, which appears to be a finding associated with several morbid conditions, especially sepsis and tumors. This indicates the need for a careful investigation of even a mild prolongation of prothrombin time, especially when fibrinogen and partial thromboplastin time are normal.
- Publication
Clinical & Applied Thrombosis/Hemostasis, 2016, Vol 22, Issue 8, p705
- ISSN
1076-0296
- Publication type
Article
- DOI
10.1177/1076029615599440