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- Title
Healthy twins delivered after oocyte cryopreservation and bilateral ovariectomy for ovarian cancer.
- Authors
Porcu, E.; Venturoli, S.; Damiano, G.; Ciotti, P. M.; Notarangelo, L.; Paradisi, R.; Moscarini, M.; Ambrosini, G.
- Abstract
Anti-neoplastic treatments have significantly increased the survival of cancer patients, but female patients risk premature menopause. Oocyte cryopreservation has been proposed as a fertility-saving option. This report describes the first live birth achieved with autologous cryopreserved oocytes in an ovariectomized borderline cancer patient. A patient with a borderline ovarian turnout asked for oocyte cryopreservation after a right adnexectomy. Ovulation induction resulted in the retrieval and cryopreservation of seven mature oocytes. Thirty-nine months after a left ovariectomy, the patient asked for oocyte thawing and embryo transfer. Endometrial growth was induced using hormone replacement treatment. Three of the seven cryopreserved oocytes were thawed: they survived and, after insemination, normal fertilization took place. Three embryos were transferred into the patient's uterus. A twin pregnancy was achieved with the birth of two healthy females. Oocyte cryopreservation may be a reliable option for preserving fertility in young cancer patients who risk premature menopause due to surgery, chemotherapy or radiotherapy.
- Subjects
TWINS; DELIVERY (Obstetrics); OVUM; CRYOPRESERVATION of organs, tissues, etc.; OVARIECTOMY; OVARIAN cancer; DRUG therapy; FERTILITY
- Publication
Reproductive BioMedicine Online (Reproductive Healthcare Limited), 2008, Vol 17, Issue 2, p265
- ISSN
1472-6483
- Publication type
Article
- DOI
10.1016/S1472-6483(10)60204-0