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- Title
Local inflammatory response in choriodecidua induced by Ureaplasma urealyticum.
- Authors
Aaltonen, R.; Heikkinen, J.; Vahlberg, T.; Jensen, J. S.; Alanen, A.
- Abstract
Ureaplasma urealyticum is the bacterial species most often connected with preterm birth, although it often colonises the amniotic fluid without any adverse effects. The induction of preterm labour seems to depend on whether the bacteria produce an inflammatory reaction. In vitro stimulation of choriodecidual tissue with high amounts of U. urealyticum or with lipopolysaccharide induced a qualitatively similar inflammatory response detected by the production of tumour necrosis factor alpha, followed by secretion of anti-inflammatory cytokine interleukin-10 and of prostaglandin E2. Lower quantities of bacteria failed to induce any response.
- Subjects
PREMATURE labor; AMNIOTIC liquid; ENDOTOXINS; PROSTAGLANDINS; INFLAMMATION; CYTOKINES; GROWTH factors
- Publication
BJOG: An International Journal of Obstetrics & Gynaecology, 2007, Vol 114, Issue 11, p1432
- ISSN
1470-0328
- Publication type
Article
- DOI
10.1111/j.1471-0528.2007.01410.x