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- Title
Distribution of genotype and allele frequencies of polymorphism C634G of VEGF-A gene in patients with diabetic retinopathy.
- Authors
FARKHADOVICH, YUSUPOV AZAMAT; KHAMITOVNA, KARIMOVA MUJASSAR; IBRAGIMOVNA, ABDULLAEVA SAYIDA; TUKHTABAEVICH, BOBOEV KODIRJON
- Abstract
Aim: To study the polymorphism of C634G gene of VEGF-A in patients with nonproliferative diabetic retinopathy. Material and research methods: The study included 40 patients with type 2 diabetes mellitus (17 men and 23 women), 48 to 70 years old (mean age - 51±2.92 years old), with NPDR, and 50 healthy individuals (mean age - 31.2+0.5 years old). All patients with diabetes mellitus and 50 healthy donors of Uzbek nationality, who made up the control group, underwent PCR genotyping of polymorphism C634G of VEGF-A gene. Results: The obtained results on polymorphism of C634G gene of VEGF-A demonstrated a high frequency of occurrence of the mutant allele G among DR patients in comparison with the control group. Conclusions: As a result of the study of the polymorphic locus C634G of the VEGF-A gene, pronounced differences between a group of patients and healthy individuals in the Uzbek population were found. In the presence of the unfavorable G allele, the risk of diabetic retinopathy development increases by more than 2.1 times.
- Subjects
GENETIC polymorphisms; DIABETIC retinopathy; PLEOMORPHIC fungi; CONTROL groups; NON-communicable diseases; DIABETES; ETHNIC groups
- Publication
International Journal of Pharmaceutical Research (09752366), 2019, Vol 11, Issue 3, p1216
- ISSN
0975-2366
- Publication type
Article
- DOI
10.31838/ijpr/2019.11.03.082