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- Title
ANTI α-GLUCOSIDASE, ANTITUMOUR, ANTIOXIDATIVE, ANTIMICROBIAL ACTIVITY, NUTRITIVE AND HEALTH PROTECTIVE POTENTIAL OF SOME SEAWEEDS FROM THE ADRIATIC COAST OF MONTENEGRO.
- Authors
MILOVIĆ, SANJA; KUNDAKOVIĆ, TATJANA; MAČIĆ, VESNA; STANKOVIĆ, JELENA ANTIĆ; GROZDANIĆ, NAĐA; ĐURIČIĆ, IVANA; STANKOVIĆ, IVAN; STANOJKOVIĆ, TATJANA
- Abstract
The aim of the present study was to reveal the potential biological activities of the dichlorometane:methanol (1:1) dry extract (DME) and the nutritional value of selected seaweeds: Cymodocea nodosa, Halimeda tuna, Cystoseira barbata and Codium bursa, collected from the Adriatic coast, Montenegro. We assessed the chemical composition and several biological activities such as: anti- α-glucosidase, antitumour, antimicrobial and antioxidative activity. H. tuna had the best cytotoxic activity against human colon carcinoma cell line, LS174 (IC50 = 17.92 ± 1.54 μg/mL). C. nodosa demonstrated strong cytotoxicity against human adenocarcinoma cell line, HeLa (IC50 = 13.28 ± 0.39 μg/mL) and human chronic myelogenous leukaemia cell line, K562 (IC50 = 19.64 ± 1.55 μg/mL). C. barbata had the best anti α-glucosidase (IC50 = 9.98 ± 3.34 μg/mL) and antimicrobial activity (minimal inhibitory concentration of 100 μg/mL) for Staphylococcus aureus and Bacillus subtilis. C. bursa showed the highest nutritional value (490.4 kcal).
- Subjects
GLUCOSIDASE inhibitors; MARINE algae; BACILLUS subtilis; ANTI-infective agents; METHANOL
- Publication
Farmacia, 2017, Vol 65, Issue 5, p731
- ISSN
0014-8237
- Publication type
Article