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- Title
Efficacy of Brachytheraphy With Californium-252 Neutrons Versus Cesium-137 Photons for Eradication of Bulky Localized Cervical Cancer: Single-Institution Study23.
- Authors
Maruyama, Yosh; van Nagell, J. R; Yoneda, Justine; Donaldson, Elvis; Gallion, Holly; Higgins, Robert; Powell, Deborah; Turner, Carol; Kryscio, Richard
- Abstract
A fast-neutron-emitting radioisotope, Cf, is being tested in clinical trials of neutron brachytherapy for cervical cancer. The efficacy for histological eradication of bulky stage IB cervical tumors (mean diameter, ∼6 cm) using combined radiation and surgery was studied in 65 patients treated with Cs or Cf before surgery during 1983–1986. Forty-four patients were treated with Cs and 21 were treated with Cf at equivalent doses of radiation. Fifteen of the 44 specimens (34%) were positive after Cs therapy. Only one of the 21 specimens was positive after Cf therapy ( = .025), and that patient was treated in a delayed schedule 21 days after the start of external-beam irradiation rather than early in the course. Cf therapy required a much lower radiation dose and shorter treatment time. The study compared tumor destruction of an identically staged human cervical tumor in situ by direct histological means, using Cf neutron therapy or conventional photon therapy at an identical and equivalent dose adjusted by a relative biological effectiveness of 6.0 for Cf.
- Publication
JNCI: Journal of the National Cancer Institute, 1988, Vol 80, Issue 7, p501
- ISSN
0027-8874
- Publication type
Article