We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
M008: Cardiac structural and functional characteristics in cushing's syndrome.
- Authors
Takagi, S.; Naruse*, M.; Tanabe, A.; Seki, M.; Tago, K.; Yoshimoto, T.; Takano, K.
- Abstract
The aim of the present study was to assess the structural and functional characteristics of the heart in Cushing's syndrome and preclinical Cushing's syndrome. Twenty patients with Cushing's syndrome (adrenal adenoma: n = 13; Cushing's disease: n = 7), eight patients with preclinical Cushing's syndrome, and essential hypertension (n = 45) were investigated by M-mode and pulse doppler echocardiography. Left ventricular mass index (LVMI), and interventricular septal thickness (IVST), and posterior wall thickness (PWT) were comparable in patients with adrenal adenoma, preclinical Cushing's syndrome, and essential hypertension and were larger than those in Cushing's disease. Although both ejection fraction and E/A were significantly decreased, there was no significant difference between the groups. Since multivariate analysis demonstrated both blood pressure (r = 0.77, p < 0.02) and duration of disease (r = 0.77, p < 0.04) as significant factors contributing to LVMI, correlation between echocardiographic parameters and clinical findings were analyzed in patients with Cushing's syndrome with disease duration longer than 5 years and preclinical Cushing's syndrome. Geometric parameters (LVMI, IVST, and PWT) were positively correlated to cortisol levels (plasma and/or urine) in addition to blood pressure, while E/A was negatively correlated to plasma cortisol level. That cortisol level in addition to blood pressure and duration of disease correlated to left ventricular structure and function in Cushing's syndrome suggests a direct action of cortisol on the heart. Early diagnosis and treatment are indispensable to avoid cardiovascular complication.Am J Hypertens (2000) 13, 301A-301A; doi:S0895-7061(00)01085-2
- Publication
American Journal of Hypertension, 2000, Vol 13, p301A
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1016/S0895-7061(00)01085-2