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- Title
The use of onabotulinum toxin A (Botox(®)) in the treatment of chronic migraine at the Parma Headache Centre: a prospective observational study.
- Authors
Russo, Marco; Manzoni, Gian; Taga, Arens; Genovese, Antonio; Veronesi, Licia; Pasquarella, Cesira; Sansebastiano, Giuliano; Torelli, Paola; Manzoni, Gian Camillo; Sansebastiano, Giuliano Ezio
- Abstract
Chronic migraine is a debilitating headache, whose treatment is often complicated by the concomitant overuse of symptomatic medication and by the poor efficacy of standard prophylactic treatments. The PREEMPT studies have demonstrated the efficacy and tolerability of onabotulinum toxin A (Botox(®)) in the treatment of this headache type. Data about its use in clinical practice are still scarce. Our study evaluated all subjects with chronic migraine who were treated with onabotulinum toxin A between February 2014 and November 2015 at the Parma Headache Centre. Botox was injected according to the PREEMPT paradigm every 3 months. The data about variations in the number of headache days and in symptomatic medication intake before and after the Botox injections were collected from the patients' headache diaries. The study also evaluated tolerability to treatment, disability, and depressive symptoms. Of the 52 treated subjects, 14 received Botox treatment for at least 9 months and showed a significant decrease in the median number of headache days (from 19 to 14.5, p = 0.011) and in the median number of days of symptomatic medications intake and symptomatic drugs. Overall, the treatment was well tolerated. The average MIDAS and BDI-II scores after 9 months were reduced, though not significantly. The treatment with Botox proved effective and well tolerated in our clinical practice. Further studies on larger patient samples will help shed light on the persistence of the drug's effect at long term and identify the predictive factors of response to treatment.
- Subjects
ITALY; BOTULINUM A toxins; HEADACHE treatment; MIGRAINE; DRUG efficacy; MENTAL depression; ACQUISITION of data; THERAPEUTICS; BOTULINUM toxin; PARASYMPATHOMIMETIC agents; CHRONIC diseases; COMPARATIVE studies; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; PSYCHOLOGICAL tests; RESEARCH; EVALUATION research; PAIN measurement; TREATMENT effectiveness; RETROSPECTIVE studies
- Publication
Neurological Sciences, 2016, Vol 37, Issue 7, p1127
- ISSN
1590-1874
- Publication type
journal article
- DOI
10.1007/s10072-016-2568-z