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- Title
Induction of caspase cascade pathway by kaempferol-3-O-rhamnoside in LNCaP prostate cancer cell lines.
- Authors
HALIMAH, ELI; DIANTINI, AJENG; DESTIANI, DIKA P.; PRADIPTA, IVAN S.; SASTRAMIHARDJA, HERRI S.; LESTARI, KERI; SUBARNAS, ANAS; ABDULAH, RIZKY; KOYAMA, HIROSHI
- Abstract
Prostate cancer has become a leading cause of mortality in humans. Previous studies have shown the potential anticancer properties of kaempferol-3-O-rhamnoside in breast cancer cell lines. In the present study, the anticancer potential of kaempferol-3-O-rhamnoside was investigated in LNCaP human prostate cancer cell lines. The inhibition of cell proliferation was investigated using MTT assays, whereas its ability to induce the caspase-cascade pathway was investigated by western blotting. The results showed that kaempferol-3-O-rhamnoside inhibits the proliferation of LNCaP cells in a dose-dependent manner by upregulating the expression of caspase-8, caspase-9, caspase-3 and poly (ADP-ribose) polymerase proteins. Although further studies are required, the results of the present study indicate the potential application of kaempferol-3-O-rhamnoside in cancer treatment.
- Subjects
PROSTATE cancer; ANTINEOPLASTIC agents; CELL lines; CANCER cells; RHAMNOSIDES
- Publication
Biomedical Reports, 2015, Vol 3, Issue 1, p115
- ISSN
2049-9434
- Publication type
Article
- DOI
10.3892/br.2014.385