We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Genetic variants in PI3K/ AKT pathway are associated with severe radiation pneumonitis in lung cancer patients treated with radiation therapy.
- Authors
Tang, Yang; Liu, Bo; Li, Jing; Wu, Huanlei; Yang, Ju; Zhou, Xiao; Yi, Mingxiao; Li, Qianxia; Yu, Shiying; Yuan, Xianglin
- Abstract
PI3K/ AKT pathway plays important roles in inflammatory and fibrotic diseases while its connection to radiation pneumonitis ( RP) is unclear. In this study, we explored the associations of genetic variants in PI3K/ AKT pathway with RP in lung cancer patients with radiotherapy. Two hundred and sixty one lung cancer patients with radiotherapy were included in this prospective study ( NCT02490319) and genotyped by MassArray and Sanger Sequence methods. By multivariate Cox hazard analysis and multiple testing, GA/ GG genotype of AKT2: rs33933140 ( HR = 0.272, 95% CI: 0.140-0.530, P = 1.3E-4, P c = 9.1E-4), and the GT/ GG genotype of PI3 CA: rs9838117 ( HR = 0.132, 95% CI: 0.042-0.416, P = 0.001, P c = 0.006) were found to be strongly associated with a decreased occurrence of RP ≥ grade 3. And patients with the CT/ TT genotype of AKT2: rs11880261 had a notably higher incidence of RP ≥ grade 3 ( HR = 2.950, 95% CI: 1.380-6.305, P = 0.005, P c = 0.025). We concluded that the genetic variants of PI3K/ AKT pathway were significantly related to RP of grade ≥ 3 and may thus be predictors of severe RP before radiotherapy, if further validated in larger population.
- Subjects
LUNG cancer; CANCER patients; RADIOLOGY; PHYSICS; PNEUMONIA
- Publication
Cancer Medicine, 2016, Vol 5, Issue 1, p24
- ISSN
2045-7634
- Publication type
Article
- DOI
10.1002/cam4.564