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- Title
Low-grade fibromyxoid sarcoma arising in the big toe.
- Authors
Kusumi, Tomomi; Nishikawa, Shinji; Tanaka, Masanori; Ogawa, Taro; Jin, Hiromichi; Sato, Fuyuki; Toh, Satoshi; Hasegawa, Tadashi; Kijima, Hiroshi
- Abstract
Low-grade fibromyxoid sarcoma (LGFMS) is a rare tumor. Reported herein is a case of LGFMS arising in the big toe. The patient was a 58-year-old man who underwent excision of the tumor. The tumor was well-demarcated. Histologically, there were proliferating spindle-shaped tumor cells arranged in a whorled growth pattern, and the stroma showed hyalinized collagen bundles and a myxoid matrix. Nuclear mitotic figures were conspicuous in part. A large rosette-like structure with hyalinized stroma was found, which is characteristic of LGFMS. The differential diagnosis included tumor occurrence in adults; tending to arise in distal extremities; and having bland fibromyxoid histological features, such as fibroma of tendon sheath, low-grade myxofibrosarcoma and acral myxoinflammatory fibroblastic sarcoma. It was not possible to detect the FUS/ CREB3L2 and FUS/ CREB3L1 fusion genes from the formalin-fixed and paraffin-embedded tissue, although the histological features of the present case were typical of LGFMS. LGFMS may become more common with time, and unique cases may accumulate.
- Subjects
SARCOMA; TOES; CANCER cells; TUMOR surgery; EXTREMITIES (Anatomy); TUMORS
- Publication
Pathology International, 2005, Vol 55, Issue 12, p802
- ISSN
1320-5463
- Publication type
Article
- DOI
10.1111/j.1440-1827.2005.01910.x