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- Title
A case of contact dermatitis due to impurities of cetyl alcohol.
- Authors
Komamura, Hiromi; Doi, Toshiaki; Inui, Shigeki; Yoshikawa, Kunihiko
- Abstract
A 29-year-old man being treated for itchy lesion on the amputation stump of the thigh became allergic to betamethasone valerate and gentamicin sulfate cream (Rinderon VG®). Closed patch tests with all the ingredients of the cream revealed positive reactions to cetyl alcohol 30% to 5%pet. Gas chromatographic analysis of the cetyl alcohol in the cream base detected stearyl alcohol (C[sub18]), myristyl alcohol (C[sub14]) and lauryl alcohol (C[sub12]) in addition to the main component of cetyl alcohol (C[sub16]). Patch testing with 99% pure analytical reagent grade saturated alcohols (C[sub10], C[sub11], C[sub12], C[sub13], C[sub14], C[sub15], C[sub16], C[sub17], C[sub18], C[sub19], C[sub20]) showed negative reactions. Thus, it is concluded that some minor impurities in cetyl alcohol not detected by gas chromatography might be the cause of this dermatitis.
- Subjects
CONTACT dermatitis; DELAYED hypersensitivity; SKIN inflammation; ALCOHOL; RESIDUAL limbs; CLINICAL indications
- Publication
Contact Dermatitis (01051873), 1997, Vol 36, Issue 1, p44
- ISSN
0105-1873
- Publication type
Article
- DOI
10.1111/j.1600-0536.1997.tb00921.x