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- Title
Brain structure and function related to headache: Brainstem structure and function in headache.
- Authors
Vila-Pueyo, Marta; Hoffmann, Jan; Romero-Reyes, Marcela; Akerman, Simon
- Abstract
<bold>Objective: </bold>To review and discuss the literature relevant to the role of brainstem structure and function in headache.<bold>Background: </bold>Primary headache disorders, such as migraine and cluster headache, are considered disorders of the brain. As well as head-related pain, these headache disorders are also associated with other neurological symptoms, such as those related to sensory, homeostatic, autonomic, cognitive and affective processing that can all occur before, during or even after headache has ceased. Many imaging studies demonstrate activation in brainstem areas that appear specifically associated with headache disorders, especially migraine, which may be related to the mechanisms of many of these symptoms. This is further supported by preclinical studies, which demonstrate that modulation of specific brainstem nuclei alters sensory processing relevant to these symptoms, including headache, cranial autonomic responses and homeostatic mechanisms.<bold>Review Focus: </bold>This review will specifically focus on the role of brainstem structures relevant to primary headaches, including medullary, pontine, and midbrain, and describe their functional role and how they relate to mechanisms of primary headaches, especially migraine.
- Subjects
PRIMARY headache disorders; CLUSTER headache; BRAIN stem; HEADACHE; MIGRAINE; MESENCEPHALON; SENSORIMOTOR integration
- Publication
Cephalalgia, 2019, Vol 39, Issue 13, p1635
- ISSN
0333-1024
- Publication type
journal article
- DOI
10.1177/0333102418784698