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- Title
High leptin levels are associated with migraine with aura.
- Authors
Pisanu, Claudia; Preisig, Martin; Castelao, Enrique; Glaus, Jennifer; Cunningham, Janet L.; Del Zompo, Maria; Merikangas, Kathleen R.; Schiöth, Helgi B.; Mwinyi, Jessica
- Abstract
Background: Migraine is a prevalent disorder characterised by recurrent headache attacks preceded or accompanied by aura in a subgroup of patients. Migraine often occurs together with major depressive disorder (MDD). Alterations of adipokine levels have been reported both in migraine and in MDD. In this cross-sectional study, we aimed to assess the associations between serum leptin and adiponectin levels and migraine or migraine subtypes. Analyses were adjusted for a lifetime history of MDD in order to investigate the association between adipokines and migraine under consideration of depression status. Methods:We included 3025 participants from the CoLaus/PsyCoLaus study. The impact of leptin and adiponectin levels on a diagnosis of migraine was analysed by binary regression analyses, adjusting for variables known to influence adipokine levels. Subgroup analyses were conducted based on the presence of aura. Results: Crude leptin levels were significantly higher in subjects with migraine than controls (Mann–Whitney U=515,102, p=6×10-7). When performing adjusted analyses, leptin levels were found to be significantly higher in subjects with migraine (odds ratio=1.22, p=0.024) and migraine with aura (odds ratio=1.34, p=0.004). Conclusion: High leptin levels might play a role in the pathogenesis of migraine and migraine with aura.
- Subjects
MIGRAINE; PRIMARY headache disorders; MENTAL depression; ADIPOKINES; ADIPONECTIN; PATIENTS
- Publication
Cephalalgia, 2017, Vol 37, Issue 5, p435
- ISSN
0333-1024
- Publication type
Article
- DOI
10.1177/0333102416648650