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- Title
Glutamine metabolism in cancers: Targeting the oxidative homeostasis.
- Authors
Tengfang Gong; Changbing Zheng; Xidan Ou; Jie Zheng; Jiayi Yu; Shuyu Chen; Yehui Duan; Wei Liu
- Abstract
Glutamine is the most abundant amino acid in blood and tissues, and the most important nutrient except for glucose in cancer cells. Over the past years, most studies have focused on the role of Gln metabolism in supporting energy metabolism rather than maintaining oxidative homeostasis. In fact, Gln is an important factor in maintaining oxidative homeostasis of cancer cells, especially in "Glutamine addicted" cancer cells. Here, this paper will review the recent scientific literature about the link between Gln metabolism and oxidative homeostasis, with an emphasis on the potential role of Gln metabolism in different cancers. Given that oxidative homeostasis is of critical importance in cancer, understanding the impacts of a Gln metabolism on oxidative homeostasis, gaining great insights into underlying molecular mechanisms, and developing effective therapeutic strategies are of great importance.
- Subjects
SCIENTIFIC literature; HOMEOSTASIS; GLUTAMINE; ENERGY metabolism; METABOLISM
- Publication
Frontiers in Oncology, 2022, Vol 12, p1
- ISSN
2234-943X
- Publication type
Article
- DOI
10.3389/fonc.2022.994672