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- Title
Antibiotic protection against recrudescence of latent <em>Aeromonas salmonicida</em> during furunculosis vaccination.
- Authors
Inglis, V.; Robertson, D.; Miller, K.; Thompson, K. D.; Richards, R. H.
- Abstract
Problems of temporary immunosuppression following vaccination against Aeromonas salmontctafa infection had to be overcome in the development of a furunculosis vaccine. Empirical observations have indicated that immunosuppression persists for some time after vaccination, rendering fish, especially sub- clinical carriers of A. salmonicida, highly vulnerable to bacterial invasion, the efficacy of simultaneous application of furunculosis vaccine and a° longr lasting amoxycillrn preparation to a population of Atlantic salmon smolts was evaluated. Control groups were treated with either vaccine alone, amoxycillin alone or were untreated. Moderate stress, simulating smolt transfer with a 5°C tempera attire rise, resulted in a rapid outbreak in mortalities reaching 100% in the vaccinates. Losses among the untreated controls were more gradual and rose to about 50%. Both amoxycillin-treated groups survived well. Further severe stress resulted in total mortalities among the untreated fish but no further losses in the amoxycillin groups. Four months after vaccination, evidence of a specific immune response was confirmed by ELISA, demonstrating circulating antibodies in the blood of vaccinates. In a severe and in a moderate challenge with A. saImonicidz the relative specific protection was 63 and 86%, respectively. Thus, effective protection against furunculosis was achieved without jeopardizing the swek during the vaccination process and with elimination of the carrier state.
- Subjects
ANTIBIOTICS; IMMUNIZATION; IMMUNODEFICIENCY; IMMUNOSUPPRESSION; VACCINATION; FURUNCULOSIS; BACTERIAL diseases in fishes
- Publication
Journal of Fish Diseases, 1996, Vol 19, Issue 5, p341
- ISSN
0140-7775
- Publication type
Article
- DOI
10.1111/j.1365-2761.1996.tb00372.x