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- Title
Role of CD4 T cell helper subsets in immune response and deviation of CD8 T cells in mice.
- Authors
Hogg, Alison; Sui, Yongjun; Ben‐Sasson, Shlomo Z.; Paul, William E.; Berzofsky, Jay A.
- Abstract
The ability of different CD4+ T cell subsets to help CD8+ T-cell response is not fully understood. Here, we found using the murine system that Th17 cells induced by IL-1β, unlike Th1, were not effective helpers for antiviral CD8 responses as measured by IFNγ-producing cells or protection against virus infection. However, they skewed CD8 responses to a Tc17 phenotype. Thus, the apparent lack of help was actually immune deviation. This skewing depended on both IL-21 and IL-23. To overcome this effect, we inhibited Th17 induction by blocking TGF-β. Anti-TGF-β allowed the IL-1β adjuvant to enhance CD8+ T-cell responses without skewing the phenotype to Tc17, thereby providing an approach to harness the benefit of common IL-1-inducing adjuvants like alum without immune deviation.
- Publication
European Journal of Immunology, 2017, Vol 47, Issue 12, p2059
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.201747091