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- Title
Exposure to SARS-CoV-2 generates T-cell memory in the absence of a detectable viral infection.
- Authors
Wang, Zhongfang; Yang, Xiaoyun; Zhong, Jiaying; Zhou, Yumin; Tang, Zhiqiang; Zhou, Haibo; He, Jun; Mei, Xinyue; Tang, Yonghong; Lin, Bijia; Chen, Zhenjun; McCluskey, James; Yang, Ji; Corbett, Alexandra J.; Ran, Pixin
- Abstract
T-cell immunity is important for recovery from COVID-19 and provides heightened immunity for re-infection. However, little is known about the SARS-CoV-2-specific T-cell immunity in virus-exposed individuals. Here we report virus-specific CD4+ and CD8+ T-cell memory in recovered COVID-19 patients and close contacts. We also demonstrate the size and quality of the memory T-cell pool of COVID-19 patients are larger and better than those of close contacts. However, the proliferation capacity, size and quality of T-cell responses in close contacts are readily distinguishable from healthy donors, suggesting close contacts are able to gain T-cell immunity against SARS-CoV-2 despite lacking a detectable infection. Additionally, asymptomatic and symptomatic COVID-19 patients contain similar levels of SARS-CoV-2-specific T-cell memory. Overall, this study demonstrates the versatility and potential of memory T cells from COVID-19 patients and close contacts, which may be important for host protection. T cells compose a critical component of the immune response to coronavirus infection with SARS-CoV-2. Here the authors characterise the T cell response to SARS CoV-2 in patients and their close contacts, and show the presence of SARS-CoV-2 specific T cells in the absence of detectable virus infection.
- Subjects
VIRUS diseases; SARS-CoV-2; COVID-19; MEMORY; IMMUNE response
- Publication
Nature Communications, 2021, Vol 12, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-021-22036-z