We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Synthesis of Aliphatic and α-Halogenated Ketone Cyanohydrins with the Hydroxynitrile Lyase from Manihot esculenta.
- Authors
Diebler, Johannes; von Langermann, Jan; Mell, Annett; Hein, Martin; Langer, Peter; Kragl, Udo
- Abstract
The potential of the hydroxynitrile lyase from Manihot esculenta towards ketone substrates was investigated. It was observed that the length of the aliphatic chain is a key parameter for the conversion of aliphatic, non-branched ketones. Smaller substrates are readily converted with high enantioselectivites, but the elongation of the chain length causes a significant loss in enzyme activity. For a number of halogenated, herein especially fluorinated, acetophenone derivatives the corresponding cyanohydrins have been synthesized with good to moderate enantioselectivities.
- Subjects
ALIPHATIC compounds; HALOGENATION; CYANOHYDRINS; LYASES; CHEMICAL synthesis; CASSAVA; KETONES
- Publication
ChemCatChem, 2014, Vol 6, Issue 4, p987
- ISSN
1867-3880
- Publication type
Article
- DOI
10.1002/cctc.201300965