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- Title
Association of VO<sub>2</sub> and VCO<sub>2</sub> rate variability with serum glucose, insulin, and glucose intolerance.
- Authors
Satué-Rodríguez, Julián; Méndez, José D.
- Abstract
Changes in the cellular metabolism assessed by the variability of oxygen consumption (VO2) and carbon dioxide production (VCO2) as well as the association of serum glucose and insulin to energy spectral density (ESD) of VO2 and VCO2 were evaluated. Ten nonglucose intolerant and 10 glucose intolerant subjects, aged 21-70 years, were included. Glucose and insulin concentrations and VO2 and VCO2 records were collected every 10 min during 3 h. ESD of VO2 and VCO2 was estimated and associated with glucose and insulin concentrations. Statistical significance in glucose levels, insulin, and ESD of VO2 and VCO2 among nonglucose intolerant subjects and glucose and insulin among glucose intolerance subjects at postload glucose (PLG) state compared with basal state was found. Moreover, glucose was significantly higher in glucose intolerance subjects than nonglucose intolerant subjects for basal and PLG states. These results show an increment in ESD of VO2 and VCO2 at PLG state among nonglucose intolerant subjects and suggest that their measurement may be a key indicator of the variability of cellular metabolic activity and contribute to confirm disturbances in glucose metabolism. © 2012 IUBMB IUBMB Life, 64(8): 705-709, 2012
- Subjects
HYPOGLYCEMIC agents; METABOLISM; BLOOD plasma; SPECTRAL energy distribution; PHOTOSYNTHETIC oxygen evolution
- Publication
IUBMB Life, 2012, Vol 64, Issue 8, p705
- ISSN
1521-6543
- Publication type
Article
- DOI
10.1002/iub.1053