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- Title
Xenotransplantation--the current status and prospects.
- Authors
Cooper, D. K. C.; Gaston, R.; Eckhoff, D.; Ladowski, J.; Yamamoto, T.; Wang, L.; Iwase, H.; Hara, H.; Tector, M.; Tector, A. J.
- Abstract
Introduction: There is a continuing worldwide shortage of organs from deceased human donors for transplantation into patients with end-stage organ failure. Genetically engineered pigs could resolve this problem, and could also provide tissues and cells for the treatment of conditions such as diabetes, Parkinson's disease and corneal blindness. Sources of data: The current literature has been reviewed. Areas of agreement: The pathobiologic barriers are now largely defined. Research progress has advanced through the increasing availability of genetically engineered pigs and novel immunosuppressive agents. Lifesupporting pig kidneys and islets have functioned for months or years in nonhuman primates. Areas of controversy: The potential risk of transfer of a pig infectious microorganism to the recipient continues to be debated. Growing points: Increased attention is being paid to selection of patients for initial clinical trials. Areas timely for developing research: Most of the advances required to justify a clinical trial have now been met.
- Subjects
KIDNEY transplantation; TRANSPLANTATION of organs, tissues, etc.; NEPHROLOGY; CLINICAL trials; MEDICAL research
- Publication
British Medical Bulletin, 2018, Vol 125, Issue 1, p5
- ISSN
0007-1420
- Publication type
Article
- DOI
10.1093/bmb/ldx043