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- Title
Identification of the STAT5B-RARα fusion transcript in an acute promyelocytic leukemia patient without FLT3, NPM1, c-Kit and C/EBPα mutation.
- Authors
Qiao, Chun; Zhang, Su-Jiang; Chen, Li-Juan; Miao, Kou-Rong; Zhang, Jian-Fu; Wu, Yu-Jie; Qiu, Hai-Rong; Li, Jian-Yong
- Abstract
T(15;17) is the most common chromosomal aberration in patients with acute promyelocytic leukemia (APL), leading to the formation of PML-RARα fusion gene. In a small subset of patients with APL, the RARα gene is fused with different partners. Here, we report a rare APL case with STAT5B-RARα fusion transcript. Cytomorphologic and immunophenotypic analyses showed typical features of APL. However, cytogenetic analysis showed normal karyotype, and interphase fluorescence in situ hybridization (FISH) showed PML-RARα negative. Quantitative RT-PCR also showed PML-RARα negative but STAT5B-RARα positive and sequencing analysis confirmed the result. Molecular markers including FLT3, NPM1, c-Kit and C/EBPα mutation were all negative. To our knowledge, this is the first APL patient with STAT5B-RARα in Chinese population and the fifth patient around the world according to published paper.
- Subjects
CASE studies; IN situ hybridization; CHROMOSOME abnormalities; ACUTE leukemia; GENES
- Publication
European Journal of Haematology, 2011, Vol 86, Issue 5, p442
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/j.1600-0609.2011.01595.x