We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The Estimation of Prevalence, Incidence, and Residual Risk of Transfusion-Transmitted Human Hepatitis B Infection from Blood Donated at the Anhui Blood Center, China, from 2009 to 2011.
- Authors
Li, Wuping; Gao, Zhan; Yang, Chunhui; Li, Jiahu; Li, Ling; Lv, Rong; Liu, Zhong
- Abstract
Background:The high prevalence of hepatitis B virus (HBV) among the Chinese population poses a threat to blood safety; however, few studies have examined epidemiological data regarding HBV infection of Chinese blood donors. The present study investigated the demographic characteristics of blood donors at the Anhui blood center in China, the prevalence, incidence, and residual risk (RR) associated with hepatitis B surface antigen (HBsAg) expression in terms of transfusion transmitted HBV (TTHBV) infections. Methods:The demographic characteristics and HBV status of people who donated blood at the Anhui blood center between 2009 and 2011 were retrospectively analyzed. The incidence of HBV was estimated through HBsAg yield approach. The window period model was then used to estimate the RR of TTHBV infection. Results:The typical donor at the Anhui blood center was a first-time volunteer, aged less than 25 years, unmarried, of Han ethnicity, and with an education below high school level. The prevalence of HBV infection among repeat donors, first-time donors, and all donors was 28.9, 127.2 and 82.1 per 100,000, respectively. The incidence estimate was 333.9 per 105 person-years. Using an infectious window period of 59 days, the RR for HBV was estimated to be 1 in 1853 between 2009 and 2011. Conclusions:The incidence and RR of HBV in Chinese blood donors are much higher than those of donors in developed countries. This is because sensitive ELISAs and nucleic acid tests are not available in China. Further work is needed to improve both the safety and availability of blood products in China.
- Subjects
CHINA; BLOOD transfusion; DISEASE prevalence; HEPATITIS B; HEPATITIS B transmission; CHINESE people; RETROSPECTIVE studies; CELL surface antigens; DISEASE risk factors; DISEASES
- Publication
PLoS ONE, 2013, Vol 8, Issue 9, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0073472