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Totalsynthese und Untersuchung der biologischen Aktivität von (−)‐Artemisinin – die Antimalaria‐Aktivität von Artemisinin ist nicht stereospezifisch.
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- Angewandte Chemie, 2018, v. 130, n. 27, p. 8425, doi. 10.1002/ange.201802015
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- Article
Total Synthesis and Biological Investigation of (−)‐Artemisinin: The Antimalarial Activity of Artemisinin Is not Stereospecific.
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- Angewandte Chemie International Edition, 2018, v. 57, n. 27, p. 8293, doi. 10.1002/anie.201802015
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- Article
Synthesis and Εvaluation of Αnticancer Αctivity in Cells of Novel Stoichiometric Pegylated Fullerene-Doxorubicin Conjugates.
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- Pharmaceutical Research, 2015, v. 32, n. 5, p. 1676, doi. 10.1007/s11095-014-1566-1
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- Article
<i>De Novo</i> Peptide Design and Experimental Validation of Histone Methyltransferase Inhibitors.
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- PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0090095
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- Article
Tripolin A, a Novel Small-Molecule Inhibitor of Aurora A Kinase, Reveals New Regulation of HURP's Distribution on Microtubules.
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- PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0058485
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- Article
New Spiro‐Lactam C‐nor‐D‐homo Steroids.
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- European Journal of Organic Chemistry, 2018, v. 2018, n. 30, p. 4147, doi. 10.1002/ejoc.201800667
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- Article
Anthraquinone Content in Noni (Morinda citrifolia L.)
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- 2013
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- Journal Article
Anthraquinone Content in Noni (Morinda citrifolia L.).
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- Evidence-based Complementary & Alternative Medicine (eCAM), 2013, v. 2013, p. 1, doi. 10.1155/2013/208378
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- Article
Current aspects of targeted therapy in head and neck tumors.
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- European Archives of Oto-Rhino-Laryngology, 2008, v. 265, p. 3, doi. 10.1007/s00405-008-0697-6
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- Article
Synthesis of the First Selective Irreversible Inhibitor of Neutral Sphingomyelinase.
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- European Journal of Organic Chemistry, 2001, v. 2001, n. 1, p. 137, doi. 10.1002/1099-0690(200101)2001:1<137::AID-EJOC137>3.0.CO;2-#
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- Article
From Substrate to Transition State Analogues: The First Potent Inhibitor of Sialyltransferases.
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- Angewandte Chemie International Edition, 1999, v. 38, n. 10, p. 1379, doi. 10.1002/(SICI)1521-3773(19990517)38:10<1379::AID-ANIE1379>3.0.CO;2-M
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- Article
Integrin Antagonists and Other Low Molecular Weight Compounds as Inhibitors of Angiogenesis: New Drugs in Cancer Therapy.
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- Angewandte Chemie International Edition, 1997, v. 36, n. 6, p. 588, doi. 10.1002/anie.199705881
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- Article
Book Review: Modern Medicinal Chemistry. (Ellis Horwood Series in Pharmaceutical Technology.) By J. B. Taylor and P. D. Kennewell.
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- Angewandte Chemie International Edition, 1995, v. 34, n. 7, p. 828, doi. 10.1002/anie.199508281
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- Article
The Sialyl Lewis<sup>x</sup> Group and its Analogues as Ligands for Selectins: Chemoenzymatic Syntheses and Biological Functions.
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- Angewandte Chemie International Edition, 1994, v. 33, n. 2, p. 178, doi. 10.1002/anie.199401781
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- Article
Peptidomimetics for Receptor Ligands-Discovery, Development, and Medical Perspectives.
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- Angewandte Chemie International Edition, 1993, v. 32, n. 9, p. 1244, doi. 10.1002/anie.199312441
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- Article
Configuratively Stable Dipeptide Aldehydes from D-Glucosamine Hydrochloride.
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- Angewandte Chemie International Edition, 1992, v. 31, n. 10, p. 1391, doi. 10.1002/anie.199213911
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- Article
LiBH<sub>4</sub>(NaBH<sub>4</sub>)/Me<sub>3</sub>SiCl, an Unusually Strong and Versatile Reducing Agent.
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- Angewandte Chemie International Edition, 1989, v. 28, n. 2, p. 218, doi. 10.1002/anie.198902181
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- Article
Guanylyl Cyclase Activation Reverses Resistive Breathing-Induced Lung Injury and Inflammation.
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- American Journal of Respiratory Cell & Molecular Biology, 2015, v. 52, n. 6, p. 762, doi. 10.1165/rcmb.2014-0092OC
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- Article
Lewis Acid Mediated Nazarov Cyclization as a Convergent and Enantioselective Entry to C-nor- D-homo-Steroids.
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- Chemistry - A European Journal, 2017, v. 23, n. 21, p. 5000, doi. 10.1002/chem.201701008
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- Article
MAZ51, an indolinone that inhibits endothelial cell and tumor cell growth in vitro, suppresses tumor growth in vivo.
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- International Journal of Cancer, 2004, v. 112, n. 6, p. 986, doi. 10.1002/ijc.20509
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- Article
The Role of Soluble Guanylyl Cyclase in Chronic Obstructive Pulmonary Disease.
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- American Journal of Respiratory & Critical Care Medicine, 2013, v. 188, n. 7, p. 789, doi. 10.1164/rccm.201210-1884OC
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- Article
Synthesis and Evaluation of Acyl Protein Thioesterase 1 (APT1) Inhibitors.
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- Chemistry - A European Journal, 2006, v. 12, n. 15, p. 4121, doi. 10.1002/chem.200501128
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- Article
Multistep Solid-Phase Synthesis of an Antibiotic and Receptor Tyrosine Kinase Inhibitors Using the Traceless Phenylhydrazide Linker.
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- Chemistry - A European Journal, 2003, v. 9, n. 14, p. 3282, doi. 10.1002/chem.200304821
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- Article
A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-Pyrones.
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- Angewandte Chemie, 2010, v. 122, n. 21, p. 3748, doi. 10.1002/ange.200906555
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- Article
Cyclopamin und der Hedgehog-Signaltransduktionsweg: Chemie, Biologie, medizinische Perspektiven.
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- Angewandte Chemie, 2010, v. 122, n. 20, p. 3492, doi. 10.1002/ange.200906967
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- Article
Bestimmung der relativen Konfiguration eines Fünfring-Lactons aus dipolaren RestkopplungenC.M.T. dankt Prof. Dr. M. Reggelin für seine Unterstützung, Dr. L. Hennig für hilfreiche Diskussionen, Dr. B. Luy und Prof. Dr. H....
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- Angewandte Chemie, 2006, v. 118, n. 27, p. 4566, doi. 10.1002/ange.200503247
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- Article
Sphingolactone: selektive und irreversibel wirkende Inhibitoren der neutralen Sphingomyelinase.
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- Angewandte Chemie, 2006, v. 118, n. 5, p. 841, doi. 10.1002/ange.200501983
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- Article
Development and Biological Evaluation of Acyl Protein Thioesterase 1 (APT1) InhibitorsThis research was supported by the Max-Planck-Gesellschaft, the Fonds der Chemischen Industrie, and the Deutsche Forschungsgemeinschaft. The authors are grateful to Prof. K. Sandhoff (Kekulé-Institut für Organische Chemie und Biochemie der Rheinischen Friedrich-Wilhelms-Universität Bonn) and Prof. F. Bordusa (Max-Planck-Forschungsstelle für Enzymologie der Proteinfaltung Halle/Saale) for helpful discussions, and to Prof. E. A. Dennis (University of California) for providing a pET vector with the APT1 coding sequence.
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- Angewandte Chemie, 2005, v. 117, n. 31, p. 5055, doi. 10.1002/ange.200462625
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- Article
Epigenetik – ein Epizentrum der Genregulation: Histone und histonmodifizierende Enzyme.
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- Angewandte Chemie, 2005, v. 117, n. 21, p. 3248, doi. 10.1002/ange.200461346
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- Article
Eine verhängnisvolle Affäre: die Ubiquitinylierung von Proteinen.
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- Angewandte Chemie, 2004, v. 116, n. 47, p. 6574, doi. 10.1002/ange.200462346
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- Article
Synthese und biochemische Eigenschaften reversibler Inhibitoren der UDP-N-Acetylglucosamin-2-Epimerase.
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- Angewandte Chemie, 2004, v. 116, n. 33, p. 4467, doi. 10.1002/ange.200453863
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- Article
Kleine Moleküle, große Pläne – können niedermolekulare Verbindungen die menschliche Regeneration steuern?
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- Angewandte Chemie, 2004, v. 116, n. 31, p. 4088, doi. 10.1002/ange.200460346
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- Article
Design, Synthese und biologische Evaluierung eines niedermolekularen Inhibitors der Histon-Acetyltransferase Gcn5Diese Arbeit wurde vom Fonds der Chemischen Industrie unterstützt. A.K. und J.P. danken für die Förderung durch...
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- Angewandte Chemie, 2004, v. 116, n. 30, p. 4065, doi. 10.1002/ange.200453879
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- Article
Synthesis and Biological Evaluation of an Indomethacin Library Reveals a New Class of Angiogenesis-Related Kinase Inhibitors ( This research was supported by the Max-Planck-Gesellschaft and the Fonds der Chemischen Industrie. ).
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- Angewandte Chemie, 2004, v. 116, n. 5, p. 547, doi. 10.1002/ange.200490006
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- Article
Synthesis and Biological Evaluation of an Indomethacin Library Reveals a New Class of Angiogenesis-Related Kinase Inhibitors ( This research was supported by the Max-Planck-Gesellschaft and the Fonds der Chemischen Industrie. ).
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- Angewandte Chemie, 2004, v. 116, n. 2, p. 226, doi. 10.1002/ange.200352582
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- Publication type:
- Article
Niedermolekulare Verbindungen als Inhibitoren Cyclin-abhängiger Kinasen.
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- Angewandte Chemie, 2003, v. 115, n. 19, p. 2170, doi. 10.1002/ange.200200540
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- Article
Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells.
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- 2007
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- Publication type:
- journal article
Increasing muscle mass improves vascular function in obese (db/db) mice.
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- 2014
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- Publication type:
- journal article
Hyperforin and aristoforin inhibit lymphatic endothelial cell proliferation in vitro and suppress tumor-induced lymphangiogenesis in vivo.
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- International Journal of Cancer, 2009, v. 125, n. 1, p. 34, doi. 10.1002/ijc.24295
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- Article
Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE).
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- 2013
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- journal article
Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase ( CBS) and cystathionine γ lyase ( CSE).
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- British Journal of Pharmacology, 2013, v. 169, n. 4, p. 922, doi. 10.1111/bph.12171
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- Article
Cover Picture: Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2 (Angew. Chem. Int. Ed. 27/2007).
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- Angewandte Chemie International Edition, 2007, v. 46, n. 27, p. 5033, doi. 10.1002/anie.200790122
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- Article
Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2.
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- Angewandte Chemie International Edition, 2007, v. 46, n. 27, p. 5219, doi. 10.1002/anie.200605207
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- Article
Determination of the Relative Configuration of a Five-Membered Lactone from Residual Dipolar Couplings C.M.T. thanks Prof. Dr. M. Reggelin for his support, Dr. L. Hennig for helpful discussions, Dr. B. Luy and Prof. Dr. H. Kessler for a gift of PS sticks, and Dr. F. Delaglio for providing the program NMRPIPE and for helping us use it. C.M.T. acknowledges the Fonds der Chemischen Industrie and the Deutsche Forschungsgemeinschaft (TH1115/1-1) for grants. R.B. acknowledges financial support by the Volkswagen Foundation as well as computer time provided by the Norddeutscher Verbund für Hoch- und Höchstleistungsrechnen (HLRN) and the Center for Scientific Computing (CSC).
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- Angewandte Chemie International Edition, 2006, v. 45, n. 27, p. 4455, doi. 10.1002/anie.200503247
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- Article
Sphingolactones: Selective and Irreversible Inhibitors of Neutral Sphingomyelinase.
- Published in:
- Angewandte Chemie International Edition, 2006, v. 45, n. 5, p. 827, doi. 10.1002/anie.200501983
- By:
- Publication type:
- Article
Development and Biological Evaluation of Acyl Protein Thioesterase 1 (APT1) InhibitorsThis research was supported by the Max-Planck-Gesellschaft, the Fonds der Chemischen Industrie, and the Deutsche Forschungsgemeinschaft. The authors are grateful to Prof. K. Sandhoff (Kekulé-Institut für Organische Chemie und Biochemie der Rheinischen Friedrich-Wilhelms-Universität Bonn) and Prof. F. Bordusa (Max-Planck-Forschungsstelle für Enzymologie der Proteinfaltung Halle/Saale) for helpful discussions, and to Prof. E. A. Dennis (University of California) for providing a pET vector with the APT1 coding sequence.
- Published in:
- Angewandte Chemie International Edition, 2005, v. 44, n. 31, p. 4975, doi. 10.1002/anie.200462625
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- Publication type:
- Article
Epigenetics—An Epicenter of Gene Regulation: Histones and Histone-Modifying Enzymes.
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- Angewandte Chemie International Edition, 2005, v. 44, n. 21, p. 3186, doi. 10.1002/anie.200461346
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- Publication type:
- Article
A Fatal Affair: The Ubiquitinylation of Proteins.
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- Angewandte Chemie International Edition, 2004, v. 43, n. 47, p. 6414, doi. 10.1002/anie.200462346
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- Publication type:
- Article
Synthesis and Biochemical Properties of Reversible Inhibitors of UDP-N-Acetylglucosamine 2-Epimerase.
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- Angewandte Chemie International Edition, 2004, v. 43, n. 33, p. 4366, doi. 10.1002/anie.200453863
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- Publication type:
- Article
Small Molecules, Big Plans—Can Low-Molecular-Weight Compounds Control Human Regeneration?
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- Angewandte Chemie International Edition, 2004, v. 43, n. 31, p. 3998, doi. 10.1002/anie.200460346
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- Publication type:
- Article