We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Quantitative Renal Perfusion Measurements in a Rat Model of Acute Kidney Injury at 3T: Testing Inter- and Intramethodical Significance of ASL and DCE-MRI.
- Authors
Zimmer, Fabian; Zöllner, Frank G.; Hoeger, Simone; Klotz, Sarah; Tsagogiorgas, Charalambos; Krämer, Bernhard K.; Schad, Lothar R.
- Abstract
Objectives: To establish arterial spin labelling (ASL) for quantitative renal perfusion measurements in a rat model at 3 Tesla and to test the diagnostic significance of ASL and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in a model of acute kidney injury (AKI). Material and Methods: ASL and DCE-MRI were consecutively employed on six Lewis rats, five of which had a unilateral ischaemic AKI. All measurements in this study were performed on a 3 Tesla MR scanner using a FAIR True-FISP approach and a TWIST sequence for ASL and DCE-MRI, respectively. Perfusion maps were calculated for both methods and the cortical perfusion of healthy and diseased kidneys was inter- and intramethodically compared using a region-of-interest based analysis. Results/Significance: Both methods produce significantly different values for the healthy and the diseased kidneys (P<0.01). The mean difference was 147±47 ml/100 g/min and 141±46 ml/100 g/min for ASL and DCE-MRI, respectively. ASL measurements yielded a mean cortical perfusion of 416±124 ml/100 g/min for the healthy and 316±102 ml/100 g/ min for the diseased kidneys. The DCE-MRI values were systematically higher and the mean cortical renal blood flow (RBF) was found to be 542±85 ml/100 g/min (healthy) and 407±119 ml/100 g/min (AKI). Conclusion: Both methods are equally able to detect abnormal perfusion in diseased (AKI) kidneys. This shows that ASL is a capable alternative to DCE-MRI regarding the detection of abnormal renal blood flow. Regarding absolute perfusion values, nontrivial differences and variations remain when comparing the two methods.
- Subjects
PERFUSION; MEASUREMENT; KIDNEY injuries; MAGNETIC resonance imaging; BLOOD flow; URINARY organs
- Publication
PLoS ONE, 2013, Vol 8, Issue 1, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0053849