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- Title
Chorioamnionitis and Neonates; Which Strategy?
- Authors
Afjeh, Seyyed-Abolfazl; Sabzehei, Mohammad Kazem; Ghanaie, Roxana Mansor; Karimizadeh, Mahdiyeh; Shamshiri, Ahmad Reza; Esmaili, Fatemeh
- Abstract
Background: Chorioamnionitis (CAM) is one of the major risk factors for neonatal early-onset sepsis (EOS). Different international guidelines have been developed for diagnosis and care of such neonates. This research aimed to evaluate our neonates and compare them with the guidelines. Methods: This prospective cohort study was conducted during five years (March 2012 to March 2017), and comprised of neonates (any gestational age) born to mothers with CAM (any criteria). The neonates' clinical findings and interventions were collected and analyzed. Results: In total, out of 28,988 live born neonates, CAM was found in mothers of 169 neonates (1.7%). Among the studied neonates, 30.8% were born ≤34 week of gestation, 39% had birth weight <2500 g, and 58.6% were asymptomatic. Out of 99 asymptomatic neonates, 47 were observed near mothers and 52 admitted to the neonatal intensive care unit (NICU). The frequency of abnormal tests was 23.07% in asymptomatic vs. 35.7% in symptomatic neonates; three neonates developed culture positive EOS (2.75%) and 68.05% of the neonates received antibiotics. The length of stay was 2.59 ± 1.13 (median = 2.00, IQR = 1.00) days in asymptomatic vs. 15.15 ± 13.67 (median = 7.00, IQR = 15.25) days in symptomatic neonates (P < 0.001). Conclusion: The use of guidelines increased the length of stay, lab tests, and antibiotics in asymptomatic and neonates with negative blood culture. In addition to the mother-neonate separation, these guidelines may increase nosocomial infection, antibiotic resistance, and costs; therefore, new guidelines are needed to be developed.
- Subjects
LOW birth weight; CELL culture; CROSS infection; DRUG resistance in microorganisms; FETAL diseases; GESTATIONAL age; LENGTH of stay in hospitals; NEWBORN infants; LONGITUDINAL method; MEDICAL care costs; MEDICAL protocols; NEONATAL intensive care; NEONATAL intensive care units; DESCRIPTIVE statistics; NEONATAL sepsis; DISEASE complications; DISEASE risk factors
- Publication
Archives of Iranian Medicine (AIM), 2020, Vol 23, Issue 7, p480
- ISSN
1029-2977
- Publication type
Article
- DOI
10.34172/aim.2020.45