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- Title
Chorioamnionitis and neurodevelopmental outcome in very preterm infants from 2007 to 2017-a population-based study.
- Authors
Konzett, Karin; Riedl, David; Stark, Carmen; Simma, Burkhard
- Abstract
<bold>Aim: </bold>The study compares neurodevelopmental outcome at 24 months corrected age of very preterm infants exposed to chorioamnionitis and controls. Peripartal parameters which may influence outcome are also investigated.<bold>Methods: </bold>In this observational population-based study, very preterm infants born between 2007 and 2017 were eligible (n = 466) and included if a histological placental examination and a complete neurodevelopmental assessment (Bayley Scale of Infant Development II or III) (n = 168) were performed. Secondary analyses were calculated to identify peripartal factors that significantly influence mental and psychomotor outcome.<bold>Results: </bold>Included infants showed a mean MDI of 91.2 (SD = 20.7) and a mean PDI of 99.4 (SD = 14.8). Infants with (n = 71) and without (n = 97) chorioamnionitis did not statistically differ either with mean MDI (91.8 vs. 90.3 points; p = 0.29) or mean PDI (98.3 vs. 100.9 points; p = 0.81), even after controlling for gestational age, mean APGAR scores and administration of antenatal steroids. Bronchopulmonary dysplasia was identified as the most influential factor for both MDI (p = .024) and PDI (p = .004).<bold>Conclusion: </bold>We could not find an effect of chorioamnionitis on neurodevelopmental outcome of very preterm infants over an eleven-year period. Analysis shows that postnatal factors have higher impacts than does chorioamnionitis.
- Subjects
PREMATURE infants; CHORIOAMNIONITIS; INFANT development; BRONCHOPULMONARY dysplasia; APGAR score; PREMATURE infant diseases; CHILD development; VERY low birth weight; GESTATIONAL age; FETAL diseases
- Publication
Acta Paediatrica, 2021, Vol 110, Issue 4, p1201
- ISSN
0803-5253
- Publication type
journal article
- DOI
10.1111/apa.15715