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- Title
The effect of post-cesarean rectal misoprostol on intestinal motility
- Authors
Adanikin, Abiodun I.; Orji, Ernest O.; Fasubaa, Olusola B.; Onwudiegwu, Uche; Ijarotimi, Omotade A.; Olaniyan, Oluwaseyi
- Abstract
Abstract: Objective: To determine whether rectally administered misoprostol can induce intestinal motility compared with oxytocin infusion when used to prevent primary postpartum hemorrhage after cesarean delivery. Methods: In a prospective randomized double-blind study in Nigeria, 218 parturients undergoing cesarean delivery who had risk factors for primary postpartum hemorrhage were enrolled between July 1, 2010, and March 31, 2011. Participants received 600μg of rectal misoprostol or 20 intravenous units of oxytocin for 4hours after surgery. The primary outcome was time until passage of flatus. Adverse effects, need for additional analgesic, and length of hospital stay were also assessed. Results: The misoprostol group had a significantly shorter mean postoperative interval to passage of flatus (20.27±7.77hours versus 38.34±10.98hours; P <0.001) and commencement of regular diet (21.08±7.69hours versus 39.13±10.94hours; P <0.001). Gastrointestinal adverse effects were more frequent, albeit not significantly, in the misoprostol group: nausea, 6.4% versus 1.8%; vomiting, 7.3% versus 2.8%; and abdominal distension, 3.7% versus 2.8%. The need for additional analgesic was the same in the 2 groups. Conclusion: After cesarean delivery, rectal misoprostol had the added benefit of inducing intestinal motility. Misoprostol might be considered in a clinical setting where postoperative ileus is anticipated.
- Subjects
MISOPROSTOL; MOTILITY of the colon; OXYTOCIN; PUERPERAL disorders; CESAREAN section; ANALGESICS; RECTAL medication
- Publication
International Journal of Gynecology & Obstetrics, 2012, Vol 119, Issue 2, p159
- ISSN
0020-7292
- Publication type
Article
- DOI
10.1016/j.ijgo.2012.05.033