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- Title
Goal-oriented cognitive rehabilitation in early-stage dementia: study protocol for a multi-centre single-blind randomised controlled trial (GREAT).
- Authors
Clare, Linda; Bayer, Antony; Burns, Alistair; Corbett, Anne; Jones, Roy; Knapp, Martin; Kopelman, Michael; Kudlicka, Aleksandra; Leroi, Iracema; Oyebode, Jan; Pool, Jackie; Woods, Bob; Whitaker, Rhiannon
- Abstract
Background: Preliminary evidence suggests that goal-oriented cognitive rehabilitation (CR) may be a clinically effective intervention for people with early-stage Alzheimer's disease, vascular or mixed dementia and their carers. This study aims to establish whether CR is a clinically effective and cost-effective intervention for people with early-stage dementia and their carers. Methods/design: In this multi-centre, single-blind randomised controlled trial, 480 people with early-stage dementia, each with a carer, will be randomised to receive either treatment as usual or cognitive rehabilitation (10 therapy sessions over 3 months, followed by 4 maintenance sessions over 6 months). We will compare the effectiveness of cognitive rehabilitation with that of treatment as usual with regard to improving self-reported and carer-rated goal performance in areas identified as causing concern by people with early-stage dementia; improving quality of life, self-efficacy, mood and cognition of people with early-stage dementia; and reducing stress levels and ameliorating quality of life for carers of participants with early-stage dementia. The incremental cost-effectiveness of goal-oriented cognitive rehabilitation compared to treatment as usual will also be examined. Discussion: If the study confirms the benefits and cost-effectiveness of cognitive rehabilitation, it will be important to examine how the goal-oriented cognitive rehabilitation approach can most effectively be integrated into routine health-care provision. Our aim is to provide training and develop materials to support the implementation of this approach following trial completion.
- Subjects
ALZHEIMER'S disease; VASCULAR dementia; QUALITY of life; COST effectiveness; BLIND experiment; RANDOMIZED controlled trials
- Publication
Trials, 2013, Vol 14, Issue 1, p1
- ISSN
1745-6215
- Publication type
Article
- DOI
10.1186/1745-6215-14-152