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- Title
Androgen Receptor Increases CD133 Expression and Progenitor-Like Population That Associate With Cisplatin Resistance in Endometrial Cancer Cell Line.
- Authors
Chen, Lumin; Chang, Wei-Chun; Hung, Yao-Ching; Chang, Ying-Yi; Bao, Bo-Yin; Huang, Hsin-Ching; Chung, Wei-Min; Shyr, Chih-Rong; Ma, Wen-Lung
- Abstract
Endometrial cancer (EMC) is a sex steroid hormone-related female malignancy. Androgen and androgen receptor (androgen/AR) signals have been implicated in EMC progression. Cancer stem/progenitor cells (CSPCs) are suspected to link to chemoresistance in patients with EMC. In this study, we examined the androgen/AR roles in cisplatin resistance and CSPC population. We found AR expression increased naive EMC side population, CSPC population, cell migration, and epithelial–mesenchymal transition. Meanwhile, it decreased cisplatin cytotoxic effect on EMC cells. Collaterally, endogenous AR expressions in EMC cells were upregulated in the cisplatin-resisting state. Moreover, AR expression could further enhance CD133 expression, CSPC-related markers, and drug-resistance gene messenger RNA expression in EMC cells. Finally, the AR-associated gene expression might go through indirect regulation. This is the first report revealing AR function on EMC cells’ CSPC and cisplatin resistance.
- Subjects
TREATMENT of endometrial cancer; DRUG resistance in cancer cells; CISPLATIN; CANCER in women; ANDROGEN receptors; PROGENITOR cells
- Publication
Reproductive Sciences, 2014, Vol 21, Issue 3, p386
- ISSN
1933-7191
- Publication type
Article
- DOI
10.1177/1933719113497281