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- Title
An overview of structure, mechanical properties, and treatment for age-related tendinopathy.
- Authors
Zhou, B.; Zhou, Y.; Tang, Kanglai
- Abstract
Tendons transfer tensile loads from muscle to bone, which enable joint motions and stabilize joints. Tendons sustain large mechanical loads in vivo and as a result, tendons were frequently injured. Aging has been confirmed as a predisposing factor of tendinopathy and bad recovery quality following tendon repair. Current treatment methods are generally not effective and involve either symptomatic relief with non-steroidal antiinflammatory drugs and physical therapy or surgery when conservative treatments failed. The limitation in treatment options is due to our incomplete knowledge of age-related tendinopathy. Studies over the past decades have uncovered a number of important mechanical and cellular changes of aging tendon. However, the basis of aging as a major risk factor for tendon injury and impaired tendon healing remained poorly understood. The objectives of this review are to provide an overview of the current knowledge about the aging-associated changes of structure, mechanical properties and treatment in tendon and highlight causes and therapies for age-related tendinopathy.
- Subjects
TENDINITIS treatment; AGE distribution; AGING; EXTRACELLULAR space; GROWTH factors; NONSTEROIDAL anti-inflammatory agents; STEM cells; TENDINITIS; TENDONS
- Publication
Journal of Nutrition, Health & Aging, 2014, Vol 18, Issue 4, p441
- ISSN
1279-7707
- Publication type
Article
- DOI
10.1007/s12603-014-0026-2