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- Title
Enhancement of Human Herpesvirus 6 Replication in Adult Human Lymphocytes by Monoclonal Antibody to CD3.
- Authors
Kikuta, Hideaki; Lu, Hua; Tomizawa, Kazuhiro; Matsumoto, Shuzo
- Abstract
The effect of monoclonal antibody to CD3 on human herpesvirus 6 (HHV-6) replication was assessed in adult peripheral blood mononuclear cells (PBMC) and in cord blood mononuclear cells (CBMC) by anticomplement immunofluorescence and Southern blot hybridization. Infection ofCBMC by HHV-6 was productive; however, little or no infection was observed with PBMC from adults exposed to the virus even if stimulated by phytohemagglutinin. Monoclonal antibody to CD3 strongly enhanced HHV-6 replicative cycles in PBMC from adults.
- Publication
Journal of Infectious Diseases, 1990, Vol 161, Issue 6, p1085
- ISSN
0022-1899
- Publication type
Article