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- Title
4q12 translocations with GSX2 expression identify a CD7<sup>+</sup> acute myeloid leukaemia subset.
- Authors
Di Giacomo, Danika; La Starza, Roberta; Barba, Gianluca; Pierini, Valentina; Baldazzi, Carmen; Storlazzi, Clelia T.; Daniele, Giulia; Forghieri, Fabio; Borlenghi, Erika; Testoni, Nicoletta; Mecucci, Cristina
- Abstract
The article discusses the research study performed by Danika Di Giacomo et al. published in "British Journal of Haematology". It mentions three cases of undifferentiated acute myeloid leukemia (AML) with 4q12 translocations where the 4q12 breakpoint was rearranged with 12p13 or with 17q22 region. It highlights that quantitative reverse transcription PCR showed gene GSX2 expression in all the three cases. It states that GSX2 expression was not detected in the CD7+ AML without 4q12-translocation.
- Subjects
CANCER research; ACUTE myeloid leukemia diagnosis; CHROMOSOMAL translocation; REVERSE transcriptase polymerase chain reaction; GENE expression
- Publication
British Journal of Haematology, 2015, Vol 171, Issue 1, p141
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.13368