We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The effect of photobiomodulation on total amount of substance P in gingival crevicular fluid: placebo-controlled randomized clinical trial.
- Authors
Doğanay Yıldız, Ezgi; Arslan, Hakan; Köseoğlu, Serhat; Arabacı, Taner; Yıldız, Dursun Anıl; Savran, Levent
- Abstract
To investigate the effect of photobiomodulation (PBM) and placebo on total amount of substance P in gingival crevicular fluid (GCF) pre- and postoperatively. Twenty-six patients having tooth with symptomatic apical periodontitis were enrolled in this study. GCF was collected preoperatively. The patients were assigned into two groups (n = 13), as follows: placebo and PBM. Sampling was repeated 7 days after root canal treatment. Two independent samples T test was used for analyzing of the differences between preoperative and postoperative substance P levels in GCF (p = .05). The Pearson correlation analysis was used for determination of correlation among substance P levels and other variables. For placebo group, there is no significant difference between preoperative and postoperative total amounts of substance P level (p = 0.553). For PBM group, postoperative total amount of substance P level was significantly higher than those of preoperative level (p = 0.005). Within the limitation of the present study, PBM has immunomodulation effect linked to the modulation of the total amount of substance P in the gingival crevicular fluid. Thai Clinical Trials Registry: TCTR20161228002.
- Subjects
GINGIVAL fluid; PERIAPICAL periodontitis; ROOT canal treatment; IMMUNOREGULATION; RANDOMIZED controlled trials; DRUG metabolism; COMPARATIVE studies; EXUDATES &; transudates; RESEARCH methodology; MEDICAL cooperation; NEUROTRANSMITTERS; PERIODONTITIS; PLACEBOS; POSTOPERATIVE pain; PREOPERATIVE care; RESEARCH; EVALUATION research
- Publication
Lasers in Medical Science, 2019, Vol 34, Issue 3, p517
- ISSN
0268-8921
- Publication type
journal article
- DOI
10.1007/s10103-018-2625-3