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- Title
HER2/neu Oncoprotein Overexpression in Epithelial Ovarian Cancer: Evaluation of its Prevalence and Prognostic Significance.
- Authors
Verri, Elena; Guglielmini, Pamela; Puntoni, Matteo; Perdelli, Luisa; Papadia, Andrea; Lorenzi, Paola; Rubagotti, Alessandra; Ragni, Nicola; Boccardo, Francesco
- Abstract
Introduction: The HER2/neu proto-oncogene encodes a transmembrane receptor protein involved in the development and progression of the majority of cancers. Prior studies have shown that HER2/neu oncogene is overexpressed in approximately 15–30% of ovarian carcinomas. However findings regarding the overexpression and prognosis are still conflicting. Methods: Our retrospective study was performed on 194 ovarian carcinoma tissues obtained at the time of first surgery. The staining procedure for HER2/neu overexpression was performed using a polyclonal antibody. Results: HER2/neu overexpression was found in 53 out of 194 (27.3%) investigated cases of which 26 (13.4%) carcinomas were weakly positive (score 1+) and 27 (13.9%) moderately (score 2+) to intensely positive (score 3+). No significant relationship was found between HER2/neu score and main clinical and pathological features. Significant difference in overall survival was evident between negative women (0/1+) and positive women (2+/3+): 48 and 29 months, respectively (p = 0.04). In multivariate analysis HER2/neu overexpression appeared to be the only variable significantly correlated with progression and death. CA125 normalization at 3 and 6 months appeared a strong predictor of progression and survival. Conclusion: In this study HER2/neu overexpression was associated with an increased risk of progression and death, especially among women with FIGO Stage I and II ovarian carcinoma. Copyright © 2005 S. Karger AG, Basel
- Subjects
OVARIES; CANCER; IMMUNOHISTOCHEMISTRY; PROTEINS; ONCOGENES
- Publication
Oncology, 2005, Vol 68, Issue 2/3, p154
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000086958