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- Title
Randomized Trial for the Control of Acute Vomiting in Cisplatin-Treated Patients: High-Dose Metoclopramide with Dexamethasone and Lorazepam as Adjuncts versus High-Dose Alizapride plus Dexamethasone and Lorazepam.
- Authors
Moreno, I.; Rosell, R.; Abad-Esteve, A.; Barnadas, A.; Carles, J.; Ribelles, N.
- Abstract
This study investigated the antiemetic activity of two different acute antiemesis regimens in patients receiving cisplatin-based chemotherapy. Seventy-four patients were treated with high-dose metoclopramide, dexamethasone and lorazepam (MDL) and 71 patients received high-dose alizapride, dexamethasone and lorazepam (ADL). Complete protection from vomiting was 50% in MDL-treated patients as compared with 30% in the ADL arm (p = 0.04). Incidence of delayed emesis was assessed in the first 82 patients accrued for the 120 h postcisplatin, being 69 and 60% in MDL and ADL, respectively. Copyright © 1991 S. Karger AG, Basel
- Publication
Oncology, 1991, Vol 48, Issue 5, p397
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000226967