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- Title
Intravesical Ropivacaine as a Novel Means of Analgesia Post-Robot-Assisted Radical Prostatectomy: A Randomized, Double-Blind, Placebo-Controlled Trial.
- Authors
Fuller, Andrew; Vanderhaeghe, Leanne; Nott, Linda; Martin, Paul R; Pautler, Stephen E.
- Abstract
Purpose: This study evaluates the safety and efficacy of intravesical ropivacaine as part of a mulitimodal approach to the provision of analgesia after robot-assisted radical prostatectomy (RARP). Patients and Methods: In this double-blind, placebo-controlled trial, 40 patients who were scheduled to undergo RARP for treatment of localized prostate cancer by a single surgeon (SP) were randomized 1:1 to receive either alkalinized intravesical ropivacaine or placebo (0.9% sodium chloride) at the completion of the vesicourethral anastomosis. A standardized general anesthetic was administered in each case. The primary outcome was a reduction in postoperative pain as assessed by a visual analogue scale (VAS). The need for alternate analgesic agents was recorded. Adverse events related to the administration of intravesical ropivacaine were documented prospectively. Results: No serious adverse events related to the administration of intravesical ropivacaine were identified. In the ropivacaine group, there was a significant reduction in the cumulative needed dose of ketoralac relative to placebo at 6 hours postoperatively. There was no statistically significant difference between the groups with regard to pain scores or narcotic use at any time point. Conclusions: Intravesical administration of ropivacaine may be used safely in the context of RARP and is associated with a significant, albeit modest reduction in the need for supplementary analgesic agents, but did not result in a decrease in postoperative pain scores.
- Subjects
ANALGESIA; PROSTATECTOMY; PLACEBOS; LOCAL anesthetics; HEALTH outcome assessment; RANDOMIZED controlled trials; BLIND experiment
- Publication
Journal of Endourology, 2013, Vol 27, Issue 3, p313
- ISSN
0892-7790
- Publication type
Article
- DOI
10.1089/end.2012.0191