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- Title
Correlation of hematological parameters, antibodies and cytokines with disease activity in systemic lupus erythematosus: a cross-sectional study.
- Authors
Živković, Valentina; Cvetković, Tatjana; Dinić, Biljana Radovanović; Jurišić, Vladimir
- Abstract
Background: The aim of the study was to investigate the association of neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte ratios (PLR) with standard inflammation parameters, including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), complement component C3, anti-double-stranded deoxyribonucleic acid (anti-dsDNA), anti-nucleosome and anti-C1q antibodies, and serum and urinary monocyte-chemoattractant protein-1 (MCP-1) with disease activity in patients with systemic lupus erythematosus (SLE). Results: This study included 160 patients (145 female and 15 male patients), hospitalized at the Rheumatology Department. A positive correlation between NLR and ESR (p < 0.01), anti-dsDNA antibodies (p < 0.05), and PLR (p < 0.001) was obtained, with a negative correlation with C3 (p < 0.005). PLR shows a positive correlation with ESR (p < 0.001), CRP (p < 0.005), anti-dsDNA antibodies (p < 0.001), anti-nucleosome antibodies (p < 0.05), and urine MCP-1 (p < 0.05), with a negative correlation with C3 (p < 0.005). Univariate analysis showed that all the examined laboratory parameters were independent predictors of disease activity (p < 0.001), while the method of standard multiple regression analysis revealed the most significant ESR and serum MCP-1 (p < 0.05). Conclusions: NLR and PLR, as inexpensive and accessible biomarkers, can help in routine clinical practice for the estimation of disease activity in SLE patients.
- Subjects
THERAPEUTIC use of immunoglobulins; THERAPEUTIC use of cytokines; C-reactive protein; STATISTICS; BIOMARKERS; PLATELET lymphocyte ratio; CROSS-sectional method; MULTIPLE regression analysis; BLOOD platelets; NEUTROPHIL lymphocyte ratio; NEUTROPHILS; BLOOD sedimentation; SYMPTOMS; DESCRIPTIVE statistics; RESEARCH funding; SYSTEMIC lupus erythematosus; BLOOD testing
- Publication
Egyptian Rheumatology & Rehabilitation, 2023, Vol 50, Issue 1, p1
- ISSN
1110-161X
- Publication type
Article
- DOI
10.1186/s43166-023-00222-9