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- Title
Neuromodulation Strategies in Post-Traumatic Stress Disorder: From Preclinical Models to Clinical Applications.
- Authors
Gouveia, Flavia V.; Gidyk, Darryl C.; Giacobbe, Peter; Ng, Enoch; Meng, Ying; Davidson, Benjamin; Abrahao, Agessandro; Lipsman, Nir; Hamani, Clement
- Abstract
Post-traumatic stress disorder (PTSD) is an often debilitating disease with a lifetime prevalence rate between 5–8%. In war veterans, these numbers are even higher, reaching approximately 10% to 25%. Although most patients benefit from the use of medications and psychotherapy, approximately 20% to 30% do not have an adequate response to conventional treatments. Neuromodulation strategies have been investigated for various psychiatric disorders with promising results, and may represent an important treatment option for individuals with difficult-to-treat forms of PTSD. We review the relevant neurocircuitry and preclinical stimulation studies in models of fear and anxiety, as well as clinical data on the use of transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation (rTMS), and deep brain stimulation (DBS) for the treatment of PTSD.
- Subjects
POST-traumatic stress disorder; TRANSCRANIAL direct current stimulation; TRANSCRANIAL magnetic stimulation; DEEP brain stimulation; PATHOLOGICAL psychology
- Publication
Brain Sciences (2076-3425), 2019, Vol 9, Issue 2, p45
- ISSN
2076-3425
- Publication type
Article
- DOI
10.3390/brainsci9020045