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- Title
Purinergic Receptors on Oligodendrocyte Progenitors: Promising Targets for Myelin Repair in Multiple Sclerosis?
- Authors
Lecca, Davide; Abbracchio, Maria P.; Fumagalli, Marta
- Abstract
Keywords: purinoceptors; GPR17; oligodendrocyte progenitors; myelin repair; multiple sclerosis EN purinoceptors GPR17 oligodendrocyte progenitors myelin repair multiple sclerosis N.PAG N.PAG 1 01/29/21 20210127 NES 210127 Introduction Multiple sclerosis (MS) is an inflammatory immune-mediated disease of the central nervous system (CNS) characterized by damage of myelin-forming oligodendrocytes and destruction of myelin itself, leaving denuded axons without trophic and metabolic support and prone to degeneration ([34]). In physiological conditions, GPR17 is almost exclusively expressed in oligodendrocytes, with a clearly characterized transient pattern: it starts to be expressed in early OPCs, reaches its peak in immature oligodendrocytes, and then disappears in myelinating oligodendrocytes ([20]). The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination. Purinoceptors, GPR17, oligodendrocyte progenitors, myelin repair, multiple sclerosis.
- Subjects
OLIGODENDROGLIA; PURINERGIC receptors; MULTIPLE sclerosis; MYELIN; CENTRAL nervous system
- Publication
Frontiers in Pharmacology, 2021, Vol 11, pN.PAG
- ISSN
1663-9812
- Publication type
Article
- DOI
10.3389/fphar.2020.629618