We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Growth hormone (GH) status is an independent determinant of serum levels of cholesterol and triglycerides in healthy adults.
- Authors
Vahl, Nina; Klausen, Ib; Christiansen, Jens S; Jørgensen, Jens O. L.
- Abstract
OBJECTIVE Both severe growth hormone (GH) deficiency in hypopituitary adults and physiological ageing are associated with an increase in fat mass, dyslipidaemia, and an increased incidence of cardiovascular disease. Ageing is also associated with a physiological decrease in spontaneous as well as stimulated GH secretion. We wished to evaluate the effects of endogenous GH status on circulating lipoproteins. DESIGN A cross-sectional study. SUBJECTS Forty-two healthy nonobese adults of both sexes (20 M + 22 F) aged 27–59 years. MEASUREMENTS Twenty-four hour GH secretion, arginine-stimulated GH secretion, and fasting values of lipoproteins and triglycerides. Body composition was measured by CT-scan and whole body DXA-scan. VO2-max was measured on an ergometer bicycle. RESULTS GH secretion decreased with age and was lower in males. Older subjects had more total body fat, subcutaneous abdominal fat, and intra-abdominal fat than younger ones, and their VO2-max was decreased. Men had more intra-abdominal and subcutaneous abdominal fat but less total body fat than women. There was no sex difference in VO2-max. Total cholesterol (TC) and LDL-C (mmol/l) were higher in older than in the younger subjects (TC: 5.32 (95% CI = 0.49) vs. 4.17 (95% CI = 0.28), P < 0.001; LDL-C: 3.66 (95% CI = 0.52) vs. 2.54 (95% CI = 0.37), P = 0.001) without sex differences. HDL-C did not show any difference with age or between sexes. Triglycerides (mmol/l) were higher in older subjects and in males (older: 1.36 (95% CI = 0.19) vs. younger: 1.02 (95% CI = 0.20), P = 0.015; M: 1.34 (95% CI = 0.24) vs. F: 1.03 (95% CI = 0.16), P = 0.03). There was no age-difference in lipoprotein (a), but concentrations were higher in women (M: 4.35 (2.95–8.30) vs. F: 19.40 (4.10–32.80), P = 0.03). TC, LDL-C, and triglycerides correlated positively with age and indices of adiposity, and inversely with VO2-max. TC, LDL-C, and triglycerides also...
- Subjects
SOMATOTROPIN; CHOLESTEROL; TRIGLYCERIDES
- Publication
Clinical Endocrinology, 1999, Vol 51, Issue 3, p309
- ISSN
0300-0664
- Publication type
Article
- DOI
10.1046/j.1365-2265.1999.00772.x