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- Title
The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part III: Polymorphisms of genes involved in Tregs' activation and function.
- Authors
Nedoszytko, Bogusław; Sokołowska-Wojdyło, Małgorzata; Renke, Joanna; Lange, Magdalena; Trzonkowski, Piotr; Sobjanek, Michał; Szczerkowska-Dobosz, Aneta; Niedoszytko, Marek; Górska, Aleksandra; Romantowski, Jan; Skokowski, Jarosław; Kalinowski, Leszek; Nowicki, Roman J.
- Abstract
Regulatory T cells (Tregs) represent a cell type that promotes immune tolerance to autologous components and maintains immune system homeostasis. The abnormal function of Tregs is relevant to the pathogenesis of several skin diseases like psoriasis, atopic dermatitis, systemic lupus erythematosus, cutaneous T-cell lymphomas, and skin cancer and is also important in rheumatoid arthritis, diabetes and other autoimmune diseases. In this review, we will summarize the role of mutations and/or polymorphisms of genes involved in Tregs development, and functions in the pathogenesis of selected skin diseases.
- Subjects
T cell differentiation; INFLAMMATORY mediators; RISK factors of skin cancer; IMMUNOLOGICAL tolerance; GENETIC polymorphisms; DNA methylation; SKIN disease genetics
- Publication
Advances in Dermatology & Allergology / Postępy Dermatologii i Alergologii, 2017, Vol 34, Issue 6, p517
- ISSN
1642-395X
- Publication type
Article
- DOI
10.5114/pdia.2017.67053