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- Title
Type I interferon production elicits differential CD4+ T-cell responses in mice infected with Plasmodium berghei ANKA and P. chabaudi.
- Authors
Ntita, Mbaya; Inoue, Shin-Ichi; Jian, Jiun-Yu; Bayarsaikhan, Ganchimeg; Kimura, Kazumi; Kimura, Daisuke; Miyakoda, Mana; Nozaki, Eriko; Sakurai, Takuya; Fernandez-Ruiz, Daniel; Heath, William R; Yui, Katsuyuki
- Abstract
Abstract Plasmodium parasites that infect humans are highly polymorphic, and induce various infections ranging from an asymptomatic state to life-threatening diseases. However, how the differences between the parasites affect host immune responses during blood-stage infection remains largely unknown. We investigated the CD4+ T-cell immune responses in mice infected with P. berghei ANKA (PbA) or P. chabaudi chabaudi AS (Pcc) using PbT-II cells, which recognize a common epitope of these parasites. In the acute phase of infection, CD4+ T-cell responses in PbA-infected mice showed a lower involvement of Th1 cells and a lower proportion of Ly6Clo effector CD4+ T cells than those in Pcc-infected mice. Transcriptome analysis of PbT-II cells indicated that type I interferon (IFN)-regulated genes were expressed at higher levels in both Th1- and Tfh-type PbT-II cells from PbA-infected mice than those from Pcc-infected mice. Moreover, IFN-α levels were considerably higher in PbA-infected mice than in Pcc-infected mice. Inhibition of type I IFN signaling increased PbT-II and partially reversed the Th1 over Tfh bias of the PbT-II cells in both PbA- and Pcc-infected mice. In the memory phase, PbT-II cells in PbA-primed mice maintained higher numbers and exhibited a better recall response to the antigen. However, recall responses were not significantly different between the infection groups after re-challenge with PbA, suggesting the effect of the inflammatory environment by the infection. These observations suggest that the differences in Plasmodium -specific CD4+ T-cell responses between PbA- and Pcc-infected mice were associated with the difference in type I IFN production during the early phase of the infection.
- Subjects
TYPE I interferons; PLASMODIUM berghei; INFECTION; T cells; TH1 cells; CD4 antigen
- Publication
International Immunology, 2022, Vol 34, Issue 1, p21
- ISSN
0953-8178
- Publication type
Article
- DOI
10.1093/intimm/dxab090