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- Title
Does Radioiodine Therapy in Patients with Differentiated Thyroid Cancer Increase the Frequency of Another Malignant Neoplasm?
- Authors
Hirosawa, Renata Midori; Marivo, Monica; de Moura Leite Luengo, Juliana; Tagliarini, Jose Vicente; Castilho, Emanuel Cellice; de Alencar Marques, Mariangela; Kiy, Yoshio; Marone, Marilia Martins Silveira; de Arruda Silveira, Liciana Vaz; Da Silva Mazeto, Glaucia Maria Ferreira
- Abstract
Objectives. To compare the frequency of another primary malignancy in patients with differentiated thyroid carcinoma (DTC) who received radioiodine therapy or not (131I). Material and Methods. 168 cases of DTC patients were retrospectively evaluated as to the frequency of another neoplasia by comparing patients with and without it, taking into account clinical, laboratory, and therapeutic parameters. Results. Another primary malignancy occurred in 8.9% of patients. Of these, 53.3% showed the malignancy before 131I and 46.7% after it. By comparing both groups, the age at the moment of diagnosis of another neoplasia was 46.1 ± 20.2 years for the group before 131I therapy and of 69.4 ± 11.4 years for the group after it (P = 0.02). Of the 148 patients treated with 131I, 4.7% developed another malignancy. The latter were older (61 ± 17 years) than those who did not show another cancer type (44.1 ± 14.2 years) (P < 0.05). Conclusion. The frequency of another neoplasia found after 131I was similar to that found before 131I.
- Subjects
THYROID cancer; IODINE isotopes; TUMORS; CANCER; PATIENTS
- Publication
ISRN Oncology, 2011, p1
- ISSN
2090-5661
- Publication type
Article
- DOI
10.5402/2011/708343